Hide
Show all
Email this article Antiacetylcholinesterase Activitie of Sweet Orange (Citrus Sinensis) Essential Oil from Algeria.
Abstract
Natural products have been the source of new drugs since ancient times. Plants are a good source of secondary metabolites which have been found to have beneficial properties. The purpose of this research was to evaluate the chemical composition by gas chromatography coupled with mass spectrometry (GCMS) and acetylcholinesterase inhibitory activity was also determined of sweet orange (Citrus sinensis) essential oil.
The main components of the essential oil were Limonene (89.547 %), β.-Myrcene (4.106 %), β.-Phellandrene (1.670 %), α.-Pinene (1.312 %).
The results of these studies clearly demonstrate that orange may represent a valuable source of new secondary metabolites with high diverse biological activities, in particular for finding new natural Acetylcholinesterase AChE inhibitors, with an (IC50 = 35.07 ± 2.47 μg. mL-1) for the essential oil compared to (IC50 = 6.27 ± 1.15 μg. mL-1) for Galantamine.
References
Ellman G.L., Courtney D., Andres V., Featherstone R.M., A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol, 7 (1961) 88-95.
Rhee I.K., Van de Meent M., Ingkaninan K., Verpoorte R., Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. Journal of Chromatography A, 915 (2001) 217-223.
Sá C.G., Cardoso K.M.F., Freitas R.M., Feitosa C.M., Effect of oral treatment with essential oil of Citrus sinensis (L) Osbeck in the retention of spatial memory in rats evaluated in the Morris water maze. Rev Ciênc Farm Básica Apl, 33 (2012) 21-215.
Miyazawa M., Yamafuji C., Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids. Journal of Agricultural and Food Chemistry, 53 (2005) 1765-1768.
Ayala J.R., Montero G., Campbell H.E., GarcÃa C., Coronado M.A., León J.A., Sagaste C.A., Pérez L.J., Extraction and Characterization of Orange Peel Essential Oil from Mexico and United States of America. Journal of Essential Oil Bearing Plants, 20 (2017) 897-914.
Roux D., Conseil en aromathérapie. Pro officina editions, 2 (2008) 187.
Chiej R., Guide vert, Les plantes médicinales. Edition Solar; (1982) 331.
Basil A., Jimenez-carmonna M.M., Clifford A.A., Extraction of rosemary by super-heated water. Journal of food chemistry, 46 (1998) 5205-5209.
Sweetman S.C., The complete drug reference. Pharmaceutical Press, 2 (2009) 1280.
Gülay Kirbaslar F., Ismail Kirbaslar S., Composition of Cold-Pressed Bitter Orange Peel Oil from Turkey. Journal of Essential Oil Research, 15:1(2003) 6-9.
Feitosa C.M., Freitas R.M., Luz NN., Bezerra M.Z., Trevisan M.T., Acetylcholinesterase inhibition by somes promising Brazilian medicinal plants. Brazilian Journal of Biology, 71 (2011) 783-789.
Carvalho R.B.F., Freitas R.M., Lima L.S., Davi da J.P., Feitosa C.M., Chemical composition and anticholinesterase activity of an active fraction of extract of Citrus limon (L.) Burm leaves. Quim Nova, 36 (2013) 1375-1379.
Conforti F., Stati G.A., Tundis R., Loizzo M.R.., Menichini F., In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer’s disease. Phytotherapy Research, 21 (2007) 427-433.
Chaiyana W., Saeio K., Hennink W.E., Okonogiet S., Characterization of potent anticholinesterase plant oil based microemulsion. International Journal of Pharmaceutics, 401 (2010) 32-40.
DOI: http://dx.doi.org/10.5281/zenodo.3551098
Refbacks
- There are currently no refbacks.
Copyright (c) 2019 Hicham Boughendjioua
_________________________________________________________________________________________________________________________
All open access articles published in AJNP are distributed under the terms of the Creative Commons Attribution- 4.0 International License
The research works published in this journal are free to be accessed. They can be shared (copied and redistributed in any medium or format) and\or adapted (remixed, transformed, and built upon the material for any purpose, commercially and\or not commercially) under the following terms: attribution (appropriate credit must be given indicating original authors, research work name and publication name mentioning if changes were made) and without adding additional restrictions (without restricting others from doing anything the actual license permits). Authors retain the full copyright of their published research works and cannot revoke these freedoms as long as the license terms are followed.