Antibacterial Activity and Aphrodisiac Potential of the Ethanolic Extracts of Fadogia agretis (Sch winffax Hiern) Stem in Male Albino Rats

Salihu Abdullahi Kiyawa

Abstract


The research is aimed to evaluate the antibacterial activity and aphrodisiac potential of the ethanolic extracts of Fadogia agrestis (rubiaceae) stem in male albino rats. The antibacterial activity of the extracts were tested on four hospital isolates of staphylococcus aureus, Escherichia coli, Pseudomonas specie and Proteus spp at a concentration of 500µg using disc diffusion method. For aphrodisiac test, healthy, white male albino rats (Rattis novergicus) weighing 270 300g aged 5.0 5.5 months and female albino rats weighing 150 180g aged 3.5 5.4 months were used for the study. The male albino rats were orally dosed with 50mg/kg, 100mg/kg and 200mg/kg body weight respectively of the extract at 24hours intervals. Their sexual behaviour was evaluated for 15 minutes each. The plants extract was found to inhibit staphylococcus aureus and Pseudomonas specie. Aphrodisiac effect of the extract resulted in significant increase in mount behaviour. The antibacterial effects suggest their possible use for the treatment of infection that showed in vitro susceptibility. Also, the increase in the mounting behavior may be responsible for the aphrodisiac effect

Keywords


Aphrodisiac potential; ethanolic extracts; fadogia agrestis; albino rats

Full Text:

PDF PDF

References


Sharma V., Thakur M., Dixit V.K., A 2012. Comparative study of ethanolic extracts of Pedalium murex Linn. fruits and Sildenafil citrate on sexual behaviors and serum testosterone level in male rats during and after treatment. J Ethnopharmacol 2012; 143: 201-206.

Pallavi K.J., Ramandeep S., Sarabjeet S,. Karam S., Mamta F., Vinod S., 2011. Aphrodisiac agents from medicinal plants: A review. J Chem Pharm Res; 3(2): 911-921.

Graybill J. R., 1988. Systemic fungal infections: diagnosis and treatment. I. Therapeutic agents. Infectious Disease Clinics of North America. 805-825.

Ng P. C., 1994. Systemic fungal infections in neonates. Arch Dis of Childhood. 71: F130-F135.

Dean D. A., Burchard K. W., 1996. Fungal infection in surgical patients. Am J Surg. 171: 374-382.

Gonzalez C. E., Venzon D., Lee S., Mueller B. U., Pizzo P. A,. Walsh T. J., 1996. Risk factors for fungemia in children infected with human immunodeficiency virus: a case-control study. Clin Infect Dis. 23: 515-521.

Bibitha B, Jisha VK, Salitha CV, Mohan S, and Valsa AK., 2002. Antibacterial activity of different plant extracts. Short communication. Indian J Microbiol, 42: 361-363.

Maghrani M., Zeggwah N., Michel J., Eddouks M., 2005. Antihypertensive effect of Lepidium sativum in spontaeneously hypertensive rats. J Ethnopharm, 102(1-2):193-197.

Hulin V., Mathot A.G., Mafart P., Dufosse L., 1998. Les proprietes anti-microbiennes des huiles essentielles et composes daromes. Sci. Aliments, 18: 563-582.

Perumal Samy R, and Ignacimuthu S., Antibacterial activity of some medicinal plants from Eastern Ghats, South India, Solai bull. J.Ethnopharmacol, 72: 39-41. (2000).

Sieradzki K, Wu SW and Tomasz A. (1999). Inactivation of the methicillin resistance gene mecA in vancomycin-resistant Staphylococcus aureus. Micro. Drug Resist. 5(4): 253-257.

Irvine, F. R., 1961. Woody plants of Ghana. Oxford University Press, Oxford, p 146

MT Yakubu, MA Akanji, AT Oladiji: 2005.Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats. Asian J Androl, 7(4), 399-404.

Yakubu, M.T., Akanji, M.A., Oladiji, A.T., 2007. Male sexual dysfunction and methods used in assessing medicinal plants with aphrodisiac potentials. Pharmacogn Rev., 1(1): 49 -56.

Bruce AA, John ED, Linda LB, Gary HG, Ari S, Mary LP, et al. Brain activation and arousal in healthy heterosexual males. Brain 2002; 125: 1014-1023.

Yakubu MT, Akanji MA. 2011. Effect of aqueous extract of Massularia acuminate steam on sexual behavior of male wister rats. Evid Based Complementary Altern Med 2011; 2011: 738103.

Baccer RW, Kirby MDK, Sherris JC, and Turek M., Antibiotic susceptibility testing by standard single disc diffusion method. American Journal of clinical pathology 45:493- 496, (1966).

Fatope, M.O., Ibrahim, H., 1993. Using the brine shrimp lethality assay. Int. J. of Pharmacognosy. 31: 4, 249.

Kirby, B.A.W., 1996. Antibiotic susceptibility testing a standard single disc method. Amer. J. of Clin. Pathol. 45:493.

Mukhtar, M.D., Okafor A.C., 2002. Bioactive Evaluation of Ethanol Extracts of Leaf and Stem – Bark of Guiera Senegalensis. Nigeria Journal of Research and Production 1 (1) Pp 114 – 121.

Wall, M.E., Krider, M.M., Krewson, C.F., Eddy, C.R., Wilaman, J. J., Correll, D.S., Gentry, H.S., 1954. Steroidal sapogenins XIII. Supplementary table of data for steroidal sapogenins VII’ , Agr. Res Serv Circ. Aic, 363, Pp 17.

Trease, G.E., Evans, W.C., 1984. Trease and Evans' pharmacognosy: a physician's guide to herbal medicine. 13th edition, Bailliere, Tindall, London.

Sofowora, E. A., 1984. Medicinal plants and traditional medicine in Africa. Pp 7 – 250. John Wiley and Sons. Chichester.

Lawler, L., 1984. Ethnobotany of the orchdicaca, In orchid review and perspectives 3 edited by Aridffi. J. Ithaca, Cornell University Press, 1954: 49-227.

Griffin, P. D., 1988. In: Dicz Falusy, Geneva, Switzerland, World Health Organization.

Cowan, M.M., 1999. Plant Products as Antimicrobial Agents, Cl Microbiol Rev, 12(4), 564–582.

Smith, R. F, Shay, D.E., 1965. Steroid lysis of protoplasts and effects of stabilizers and steroid antagonists, Appl Environ Microbiol, 13(5), 706-712.

Olekszek, W.A., Hoagland, R.E., Zalblotowicz, R.M., 1999. Ecological significance of plant saponins, Principles and Practices of Plant Ecology, (CRC Press LLC, Boca. Raton, FL), 451-465.

Gee, J.M., Wortley, G.M., Johnson, I.T., Price, K.R., Rutten, A.A.J., 1996. Effect of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparations in vitro, Toxicol in Vitro, 10 (1996) 117-128.

Scalbert, A., 1991. Antimicrobial properties of tannins, Phytochemistry, 30(12), 3875-3883.

Hopkins, W., 1999. Introduction to Plant Physiology, (New York: John Wiley and Sons, Inc.), 493.

Rahman S., Parves A.K., Islam R., Kahn M.H., 2011. Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh, Ann Cl Microbiol Antimicrob, 10, 10.

Pangan A.C., Uy F.A., Oclarit J.M., 2007. Antimicrobial properties of some marine sponges (Porifera) from Mactan, Cebu, Philippines, The Philippine Scientist, 44, 35-45.

Viveiros M., Dupont M., Rodrigues L., Couto I., Davin-Regli A., 2007. Antibiotic stress, genetic response and altered permeability of E. coli, Plos One, 2 (4), 365.


Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2016 ALGERIAN JOURNAL OF NATURAL PRODUCTS

_________________________________________________________________________________________________________________________

 All open access articles published in AJNP are distributed under the terms of the  Creative Commons Attribution-  4.0 International License

The research works published in this journal are free to be accessed. They can be shared (copied and redistributed in any medium or format) and\or adapted (remixed, transformed, and built upon the material for any purpose, commercially and\or not commercially) under the following terms: attribution (appropriate credit must be given indicating original authors, research work name and publication name mentioning if changes were made) and without adding additional restrictions (without restricting others from doing anything the actual license permits). Authors retain the full copyright of their published research works and cannot revoke these freedoms as long as the license terms are followed.

 

 Flag Counter