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Email this article Inhibitory / Excitatory Effect of Starchytarpheta jamaicensis, Garcinia kola and its Synergistic Combination in Intraocular Pressure of New Zealand rabbits
Abstract
It has been reported that certain herbal preparations aid the control of Intraocular pressure (IOP). The aim of this study was to investigate the Inhibitory/excitatory effect of Starchytarpheta jamaicensis, Garcinia kola and its combination in intraocular pressure. Using standard protocol, fifty five (55) healthy adult New Zealand rabbits (n=5) were topically administered with aqueous extracts of Starchytarpheta jamaicensis (SJ), Garcinia kola (GK) and the synergic combination after induced with 1% prednisolone for 14 days to trigger intraocular pressure (IOP) in rabbits. The control groups were administered with prednisolone, and 0.5% Timolol. The test groups received graded doses (0.00351, 0.00702 and 0.0143 kg/l) of aqueous extracts of SJ, GK and the combination. The internal and external eye examination were observed across the groups using penlight/hand magnifier and ophthalmoscope to determine the IOP baseline measurements using Perkins hand held tonometer was obtained with an increased value of >5 mmHg above the baseline. The result obtained from this present study showed a significant decrease (p<0.05) in the mean intraocular pressure across the treatment groups {Starchytarpheta jamaicensis (6.33±0.58 mmHg), Garcinia kola (6.11±0.29 mmHg) and synergic combination (5.33 ± 0.29 mmHg)} when compared with IOP group (13.00±1.00 mmHg). Thereafter there was a gradual decrease until the baseline intraocular pressure of 6.50±0.87 mmHg was attained. In conclusion, Stachytarpheta jamaicensis, Garcinia kola and its synergic combination showed its decreasing effect on intraocular pressure, hence aid in the management of ocular hypertension and glaucoma.
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